5CYI

CDK2/Cyclin A covalent complex with 6-(cyclohexylmethoxy)-N-(4-(vinylsulfonyl)phenyl)-9H-purin-2-amine (NU6300)

Summary for 5CYI

Entry DOI	10.2210/pdb5cyi/pdb
Descriptor	Cyclin-dependent kinase 2, Cyclin-A2, 6-(cyclohexylmethoxy)-N-[4-(ethylsulfonyl)phenyl]-9H-purin-2-amine, ... (4 entities in total)
Functional Keywords	cdk2 cyclin a covalent inhibitor vinylsulphone, transferase
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 Nucleus : P20248
Total number of polymer chains	4
Total formula weight	129536.08
Authors	Anscombe, E.,Meschini, E.,Vidal, R.M.,Martin, M.P.,Staunton, D.,Geitmann, M.,Danielson, U.H.,Stanley, W.A.,Wang, L.Z.,Reuillon, T.,Golding, B.T.,Cano, C.,Newell, D.R.,Noble, M.E.M.,Wedge, S.R.,Endicott, J.A.,Griffin, R.J. (deposition date: 2015-07-30, release date: 2015-09-16, Last modification date: 2024-01-10)
Primary citation	Anscombe, E.,Meschini, E.,Mora-Vidal, R.,Martin, M.P.,Staunton, D.,Geitmann, M.,Danielson, U.H.,Stanley, W.A.,Wang, L.Z.,Reuillon, T.,Golding, B.T.,Cano, C.,Newell, D.R.,Noble, M.E.,Wedge, S.R.,Endicott, J.A.,Griffin, R.J. Identification and Characterization of an Irreversible Inhibitor of CDK2. Chem.Biol., 22:1159-1164, 2015 Cited by PubMed: 26320860 DOI: 10.1016/j.chembiol.2015.07.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation