5CXW

Structure of the PonA1 protein from Mycobacterium Tuberculosis in complex with penicillin V

5CXW の概要

• エントリーDOI: 10.2210/pdb5cxw/pdb
• 関連するPDBエントリー: 5CRF
• 分子名称: Penicillin-binding protein 1A, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, (2R,4S)-5,5-dimethyl-2-{(1R)-2-oxo-1-[(phenoxyacetyl)amino]ethyl}-1,3-thiazolidine-4-carboxylic acid, ... (5 entities in total)
• 機能のキーワード: b-lactam, pbp, structural genomics, psi-biology, midwest center for structural genomics, mcsg, structures of mtb proteins conferring susceptibility to known mtb inhibitors, mtbi, penicillin-binding protein-antibiotic complex, penicillin-binding protein/antibiotic
• 由来する生物種: Mycobacterium tuberculosis
• 細胞内の位置: Cell membrane ; Single-pass membrane protein : P71707
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45112.30

構造登録者

Filippova, E.V.,Kiryukhina, O.,Kieser, K.,Endres, M.,Rubin, E.,Sacchettini, J.,Joachimiak, A.,Anderson, W.F.,Midwest Center for Structural Genomics (MCSG),Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI) (登録日: 2015-07-29, 公開日: 2016-05-04, 最終更新日: 2023-09-27)

• 主引用文献: Filippova, E.V.,Kieser, K.J.,Luan, C.H.,Wawrzak, Z.,Kiryukhina, O.,Rubin, E.J.,Anderson, W.F.; Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance.; Febs J., 283:2206-2218, 2016; PubMed: 27101811; DOI: 10.1111/febs.13738

実験手法

X-RAY DIFFRACTION (1.75 Å)