5CXG

Crystal structure of Mycobacterium tuberculosis KstR in complex with PEG

Summary for 5CXG

• Entry DOI: 10.2210/pdb5cxg/pdb
• Related: 3MNL 5CW8
• Descriptor: HTH-type transcriptional repressor KstR, TRIETHYLENE GLYCOL, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
• Functional Keywords: transcriptional repressor, tetr family transcriptional repressor, cholesterol catabolism, coa thioester ligand, structural genomics, tb structural genomics consortium, tbsgc, transcription regulator
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 4
• Total formula weight: 89966.68

Authors

Ho, N.A.T.,Dawes, S.,Kendall, S.,Baker, E.N.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2015-07-28, release date: 2016-02-17, Last modification date: 2023-09-27)

• Primary citation: Ho, N.A.,Dawes, S.S.,Crowe, A.M.,Casabon, I.,Gao, C.,Kendall, S.L.,Baker, E.N.,Eltis, L.D.,Lott, J.S.; The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.; J.Biol.Chem., 291:7256-7266, 2016; PubMed: 26858250; DOI: 10.1074/jbc.M115.707760

Experimental method

X-RAY DIFFRACTION (2.1001 Å)