5CTE
Humanized yeast ACC carboxyltransferase domain bound to 2,2-dimethylpropyl (1S)-1-methyl-8-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,8-diazaspiro[4.5]decane-2-carboxylate
Summary for 5CTE
Entry DOI | 10.2210/pdb5cte/pdb |
Related | 5CTB 5CTC |
Descriptor | Acetyl-CoA carboxylase, 2,2-dimethylpropyl (1S)-1-methyl-8-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,8-diazaspiro[4.5]decane-2-carboxylate, SULFATE ION, ... (4 entities in total) |
Functional Keywords | acc, inhibitors, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Saccharomyces cerevisiae (Baker's yeast) |
Cellular location | Cytoplasm: Q00955 |
Total number of polymer chains | 2 |
Total formula weight | 175390.85 |
Authors | Vajdos, F.F. (deposition date: 2015-07-23, release date: 2015-10-14, Last modification date: 2024-03-06) |
Primary citation | Kung, D.W.,Griffith, D.A.,Esler, W.P.,Vajdos, F.F.,Mathiowetz, A.M.,Doran, S.D.,Amor, P.A.,Bagley, S.W.,Banks, T.,Cabral, S.,Ford, K.,Garcia-Irizarry, C.N.,Landis, M.S.,Loomis, K.,McPherson, K.,Niosi, M.,Rockwell, K.L.,Rose, C.,Smith, A.C.,Southers, J.A.,Tapley, S.,Tu, M.,Valentine, J.J. Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase. Bioorg.Med.Chem.Lett., 25:5352-5356, 2015 Cited by PubMed: 26411795DOI: 10.1016/j.bmcl.2015.09.035 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
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