5CSZ

CRYSTAL STRUCTURE OF GANTENERUMAB FAB FRAGMENT IN COMPLEX WITH ABETA 1-11

5CSZ の概要

• エントリーDOI: 10.2210/pdb5csz/pdb
• 分子名称: GANTENERUMAB FAB FRAGMENT HEAVY CHAIN, GANTENERUMAB FAB FRAGMENT LIGHT CHAIN, Amyloid beta A4 protein, ... (6 entities in total)
• 機能のキーワード: antibody, alzheimer, abeta, gantenerumab, gant_abeta_1_11 09-a, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 98421.40

構造登録者

Benz, J.,Burger, D.,Loetscher, H.R.,Bohrmann, B. (登録日: 2015-07-23, 公開日: 2015-08-12, 最終更新日: 2020-07-29)

• 主引用文献: Bohrmann, B.,Baumann, K.,Benz, J.,Gerber, F.,Huber, W.,Knoflach, F.,Messer, J.,Oroszlan, K.,Rauchenberger, R.,Richter, W.F.,Rothe, C.,Urban, M.,Bardroff, M.,Winter, M.,Nordstedt, C.,Loetscher, H.; Gantenerumab: a novel human anti-Abeta antibody demonstrates sustained cerebral amyloid-Beta binding and elicits cell-mediated removal of human amyloid-Beta.; J. Alzheimers Dis., 28:49-69, 2012; PubMed: 21955818; DOI: 10.3233/JAD-2011-110977

実験手法

X-RAY DIFFRACTION (1.8 Å)