5CSX

CRYSTAL STRUCTURE OF B-RAF IN COMPLEX WITH BI 882370

5CSX の概要

• エントリーDOI: 10.2210/pdb5csx/pdb
• 分子名称: Serine/threonine-protein kinase B-raf, N-(3-{5-[(1-ethylpiperidin-4-yl)(methyl)amino]-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl}-2,4-difluorophenyl)propane-1-sulfonamide, alpha-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32779.52

構造登録者

Bader, G.,Stadtmuller, H.,Steurer, S. (登録日: 2015-07-23, 公開日: 2016-03-09, 最終更新日: 2024-01-10)

• 主引用文献: Waizenegger, I.C.,Baum, A.,Steurer, S.,Stadtmuller, H.,Bader, G.,Schaaf, O.,Garin-Chesa, P.,Schlattl, A.,Schweifer, N.,Haslinger, C.,Colbatzky, F.,Mousa, S.,Kalkuhl, A.,Kraut, N.,Adolf, G.R.; A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation.; Mol.Cancer Ther., 15:354-365, 2016; PubMed: 26916115; DOI: 10.1158/1535-7163.MCT-15-0617

実験手法

X-RAY DIFFRACTION (2.51 Å)