5CRF

Structure of the penicillin-binding protein PonA1 from Mycobacterium Tuberculosis

5CRF の概要

• エントリーDOI: 10.2210/pdb5crf/pdb
• 関連するPDBエントリー: 5CXW
• 分子名称: Penicillin-binding protein 1A, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: b-lactam, pbp, structural genomics, psi-biology, midwest center for structural genomics, mcsg, structures of mtb proteins conferring susceptibility to known mtb inhibitors, mtbi, penicillin-binding protein
• 由来する生物種: Mycobacterium tuberculosis
• 細胞内の位置: Cell membrane ; Single-pass membrane protein : P71707
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 179025.28

構造登録者

Filippova, E.V.,Wawrzak, Z.,Kiryukhina, O.,Kieser, K.,Endres, M.,Rubin, E.,Sacchettini, J.,Joachimiak, A.,Anderson, W.F.,Midwest Center for Structural Genomics (MCSG),Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI) (登録日: 2015-07-22, 公開日: 2016-05-04, 最終更新日: 2016-07-06)

• 主引用文献: Filippova, E.V.,Kieser, K.J.,Luan, C.H.,Wawrzak, Z.,Kiryukhina, O.,Rubin, E.J.,Anderson, W.F.; Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance.; Febs J., 283:2206-2218, 2016; PubMed: 27101811; DOI: 10.1111/febs.13738

実験手法

X-RAY DIFFRACTION (1.8 Å)