5CPR

The novel SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity

Summary for 5CPR

Entry DOI	10.2210/pdb5cpr/pdb
Descriptor	Histone-lysine N-methyltransferase SUV420H1, ZINC ION, S-ADENOSYLMETHIONINE, ... (5 entities in total)
Functional Keywords	protein lysine transferase, h4k20, non-homologous end joining, transferase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : Q4FZB7
Total number of polymer chains	1
Total formula weight	31748.09
Authors	Jakob, C.G.,Upadhyay, A.K.,Sun, C. (deposition date: 2015-07-21, release date: 2017-01-25, Last modification date: 2023-09-27)
Primary citation	Bromberg, K.D.,Mitchell, T.R.,Upadhyay, A.K.,Jakob, C.G.,Jhala, M.A.,Comess, K.M.,Lasko, L.M.,Li, C.,Tuzon, C.T.,Dai, Y.,Li, F.,Eram, M.S.,Nuber, A.,Soni, N.B.,Manaves, V.,Algire, M.A.,Sweis, R.F.,Torrent, M.,Schotta, G.,Sun, C.,Michaelides, M.R.,Shoemaker, A.R.,Arrowsmith, C.H.,Brown, P.J.,Santhakumar, V.,Martin, A.,Rice, J.C.,Chiang, G.G.,Vedadi, M.,Barsyte-Lovejoy, D.,Pappano, W.N. The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nat. Chem. Biol., 13:317-324, 2017 Cited by PubMed: 28114273 DOI: 10.1038/nchembio.2282 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.22 Å)

Structure validation