5CPR
The novel SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity
Summary for 5CPR
Entry DOI | 10.2210/pdb5cpr/pdb |
Descriptor | Histone-lysine N-methyltransferase SUV420H1, ZINC ION, S-ADENOSYLMETHIONINE, ... (5 entities in total) |
Functional Keywords | protein lysine transferase, h4k20, non-homologous end joining, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q4FZB7 |
Total number of polymer chains | 1 |
Total formula weight | 31748.09 |
Authors | Jakob, C.G.,Upadhyay, A.K.,Sun, C. (deposition date: 2015-07-21, release date: 2017-01-25, Last modification date: 2023-09-27) |
Primary citation | Bromberg, K.D.,Mitchell, T.R.,Upadhyay, A.K.,Jakob, C.G.,Jhala, M.A.,Comess, K.M.,Lasko, L.M.,Li, C.,Tuzon, C.T.,Dai, Y.,Li, F.,Eram, M.S.,Nuber, A.,Soni, N.B.,Manaves, V.,Algire, M.A.,Sweis, R.F.,Torrent, M.,Schotta, G.,Sun, C.,Michaelides, M.R.,Shoemaker, A.R.,Arrowsmith, C.H.,Brown, P.J.,Santhakumar, V.,Martin, A.,Rice, J.C.,Chiang, G.G.,Vedadi, M.,Barsyte-Lovejoy, D.,Pappano, W.N. The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nat. Chem. Biol., 13:317-324, 2017 Cited by PubMed: 28114273DOI: 10.1038/nchembio.2282 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.22 Å) |
Structure validation
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