5COP

X-ray crystal structure of wild type HIV-1 protease in complex with GRL-097

Summary for 5COP

• Entry DOI: 10.2210/pdb5cop/pdb
• Related: 4HLA 5COK 5CON 5COO
• Descriptor: HIV-1 protease, (3R,3aS,4S,7aS)-3-hydroxyhexahydro-4H-furo[2,3-b]pyran-4-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-(4-methoxyphenyl)butan-2-yl]carbamate (3 entities in total)
• Functional Keywords: grl-097, hiv-1 protease, protease-inhibitor, darunavir, tp-thf, nonpeptidic, hydroxyl, o-methoxy., hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22213.26

Authors

Yedidi, R.S.,Hayashi, H.,Aoki, M.,Das, D.,Ghosh, A.K.,Mitsuya, H. (deposition date: 2015-07-20, release date: 2016-01-13, Last modification date: 2024-03-06)

• Primary citation: Aoki, M.,Hayashi, H.,Yedidi, R.S.,Martyr, C.D.,Takamatsu, Y.,Aoki-Ogata, H.,Nakamura, T.,Nakata, H.,Das, D.,Yamagata, Y.,Ghosh, A.K.,Mitsuya, H.; C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir.; J.Virol., 90:2180-2194, 2015; PubMed: 26581995; DOI: 10.1128/JVI.01829-15

Experimental method

X-RAY DIFFRACTION (2 Å)