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5CLP

Crystal Structure of CK2alpha with 3,4-dichlorophenethylamine bound

Summary for 5CLP
Entry DOI10.2210/pdb5clp/pdb
DescriptorCasein kinase II subunit alpha, 2-(3,4-dichlorophenyl)ethanamine, ACETATE ION, ... (4 entities in total)
Functional Keywordstransferase, ck2alpha, ck2a, fragment based drug discovery, high concentration screening, selective atp competitive inhibitors, surface entrophy reduction
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : P68400
Total number of polymer chains2
Total formula weight85203.49
Authors
Brear, P.,De Fusco, C.,Georgiou, K.H.,Spring, D.,Hyvonen, M. (deposition date: 2015-07-16, release date: 2016-07-27, Last modification date: 2024-01-10)
Primary citationBrear, P.,De Fusco, C.,Hadje Georgiou, K.,Francis-Newton, N.J.,Stubbs, C.J.,Sore, H.F.,Venkitaraman, A.R.,Abell, C.,Spring, D.R.,Hyvonen, M.
Specific inhibition of CK2 alpha from an anchor outside the active site.
Chem Sci, 7:6839-6845, 2016
Cited by
PubMed: 28451126
DOI: 10.1039/c6sc02335e
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.684 Å)
Structure validation

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