5CJF

The crystal structure of the human carbonic anhydrase XIV in complex with a 1,1'-biphenyl-4-sulfonamide inhibitor.

Summary for 5CJF

• Entry DOI: 10.2210/pdb5cjf/pdb
• Related: 4LU3
• Descriptor: Carbonic anhydrase 14, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (7 entities in total)
• Functional Keywords: 1, 1'-biphenyl-4-sulfonamide, lyase, glycoprotein, zinc-binding, complex, inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 32927.63

Authors

Alterio, V.,De Simone, G. (deposition date: 2015-07-14, release date: 2015-11-04, Last modification date: 2024-01-10)

• Primary citation: La Regina, G.,Coluccia, A.,Famiglini, V.,Pelliccia, S.,Monti, L.,Vullo, D.,Nuti, E.,Alterio, V.,De Simone, G.,Monti, S.M.,Pan, P.,Parkkila, S.,Supuran, C.T.,Rossello, A.,Silvestri, R.; Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors.; J.Med.Chem., 58:8564-8572, 2015; PubMed: 26497049; DOI: 10.1021/acs.jmedchem.5b01144

Experimental method

X-RAY DIFFRACTION (1.83 Å)