5CJF
The crystal structure of the human carbonic anhydrase XIV in complex with a 1,1'-biphenyl-4-sulfonamide inhibitor.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Carbonic anhydrase 14 | polymer | 279 | 31318.7 | 1 | UniProt (Q9ULX7) Pfam (PF00194) | Homo sapiens (Human) | Carbonate dehydratase XIV,Carbonic anhydrase XIV,CA-XIV |
| 2 | B (B) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | 4'-(4-aminobenzoyl)biphenyl-4-sulfonamide | non-polymer | 352.4 | 1 | Chemie (520) | |||
| 5 | E, F (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | G (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 7 | H (A) | water | water | 18.0 | 228 | Chemie (HOH) |
Sequence modifications
A: -1 - 272 (UniProt: Q9ULX7)
| PDB | External Database | Details |
|---|---|---|
| Leu 273 | - | expression tag |
| Val 274 | - | expression tag |
| Pro 275 | - | expression tag |
| Arg 276 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31318.7 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 910.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 698.1 | |
| All* | Total formula weight | 32927.6 |
