5CIR

Crystal structure of death receptor 4 (DR4; TNFFRSF10A) bound to TRAIL (TNFSF10)

5CIR の概要

• エントリーDOI: 10.2210/pdb5cir/pdb
• 分子名称: Tumor necrosis factor ligand superfamily member 10, Tumor necrosis factor receptor superfamily member 10A, ZINC ION, ... (5 entities in total)
• 機能のキーワード: apoptosis, binding and specificity, ligand-receptor complex, tnf receptor family
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Membrane ; Single-pass type II membrane protein : P50591; Membrane; Single-pass type I membrane protein: O00220
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 94304.86

構造登録者

Sheriff, S. (登録日: 2015-07-13, 公開日: 2017-01-18, 最終更新日: 2024-11-06)

主引用文献

Ramamurthy, V.,Yamniuk, A.P.,Lawrence, E.J.,Yong, W.,Schneeweis, L.A.,Cheng, L.,Murdock, M.,Corbett, M.J.,Doyle, M.L.,Sheriff, S.
The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex.
Acta Crystallogr F Struct Biol Commun, 71:1273-1281, 2015

PubMed Abstract: The structure of death receptor 4 (DR4) in complex with TNF-related apoptosis-inducing ligand (TRAIL) has been determined at 3 Å resolution and compared with those of previously determined DR5-TRAIL complexes. Consistent with the high sequence similarity between DR4 and DR5, the overall arrangement of the DR4-TRAIL complex does not differ substantially from that of the DR5-TRAIL complex. However, subtle differences are apparent. In addition, solution interaction studies were carried out that show differences in the thermodynamics of binding DR4 or DR5 with TRAIL.

PubMed: 26457518
DOI: 10.1107/S2053230X15016416

実験手法

X-RAY DIFFRACTION (3 Å)