5CHP

T. maritima ThyX in complex with TyC5-03

Summary for 5CHP

• Entry DOI: 10.2210/pdb5chp/pdb
• Descriptor: Thymidylate synthase ThyX, FLAVIN-ADENINE DINUCLEOTIDE, (2S)-2-[(3-hydroxy-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)sulfanyl]propanoic acid, ... (4 entities in total)
• Functional Keywords: thyx in complex with inhibitor, hydrolase
• Biological source: Thermotoga maritima
• Total number of polymer chains: 1
• Total formula weight: 28780.75

Authors

Surade, S.,Luciani, R.,Saxena, P.,Santucci, M.,Ferrari, S.,Venturelli, A.,Marverti, G.,Ponterini, G.,Abell, C.A.,Blundell, T.L.,Costi, M.P. (deposition date: 2015-07-10, release date: 2016-10-19, Last modification date: 2024-01-10)

• Primary citation: Surade, S.; Identification of inhibitors targeting substrate-binding site in Mycobacterium tuberculosis FAD-dependent Thymidylate synthase (ThyX) through Virtual Screening: A New study de-fining the binding mechanism of Inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)