5CGX

CRYSTAL STRUCTURE OF Fox-4 cephamycinase mutant Y150F complexed with cefoxitin

Summary for 5CGX

• Entry DOI: 10.2210/pdb5cgx/pdb
• Related: 5CGS 5CGW 5CHJ 5CHM
• Descriptor: Beta-lactamase, (2R)-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, ZINC ION, ... (5 entities in total)
• Functional Keywords: beta-lactamase, hydrolase
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 39575.67

Authors

Malashkevich, V.N.,Toro, R.,Lefurgy, S.,Almo, S.C. (deposition date: 2015-07-09, release date: 2016-02-03, Last modification date: 2023-09-27)

• Primary citation: Lefurgy, S.T.,Malashkevich, V.N.,Aguilan, J.T.,Nieves, E.,Mundorff, E.C.,Biju, B.,Noel, M.A.,Toro, R.,Baiwir, D.,Papp-Wallace, K.M.,Almo, S.C.,Frere, J.M.,Bou, G.,Bonomo, R.A.; FOX-4 cephamycinase: an analysis of structure and function.; Antimicrob.Agents Chemother., 2015; PubMed: 26525784; DOI: 10.1128/AAC.01887-15

Experimental method

X-RAY DIFFRACTION (1.21 Å)