5CGE

Structure of Hydroxyethylthiazole Kinase ThiM from Staphylococcus aureus in complex with substrate analog 2-(2-methyl-1H-imidazole-1-yl)ethanol

Summary for 5CGE

Entry DOI	10.2210/pdb5cge/pdb
Related	5CGA
Descriptor	Hydroxyethylthiazole kinase, 2-(2-methyl-1H-imidazol-1-yl)ethanol, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	bacterial thiamine biosynthesis, hydroxyethylthiazole kinase, substrate analog, transferase
Biological source	Staphylococcus aureus subsp. aureus MRSA252
Total number of polymer chains	6
Total formula weight	179845.27
Authors	Kuenz, M.,Drebes, J.,Windshuegel, B.,Cang, H.,Wrenger, C.,Betzel, C. (deposition date: 2015-07-09, release date: 2016-03-23, Last modification date: 2018-03-07)
Primary citation	Drebes, J.,Kunz, M.,Windshugel, B.,Kikhney, A.G.,Muller, I.B.,Eberle, R.J.,Oberthur, D.,Cang, H.,Svergun, D.I.,Perbandt, M.,Betzel, C.,Wrenger, C. Structure of ThiM from Vitamin B1 biosynthetic pathway of Staphylococcus aureus - Insights into a novel pro-drug approach addressing MRSA infections. Sci Rep, 6:22871-22871, 2016 Cited by PubMed: 26960569 DOI: 10.1038/srep22871 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.62 Å)

Structure validation