5CGA
Structure of Hydroxyethylthiazole kinase ThiM from Staphylococcus aureus in complex with substrate analog 2-(1,3,5-trimethyl-1H-pyrazole-4-yl)ethanol
Summary for 5CGA
Entry DOI | 10.2210/pdb5cga/pdb |
Descriptor | Hydroxyethylthiazole kinase, 2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethanol, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | bacterial thiamine biosynthesis, hydroxyethylthiazole kinase, substrate analog, transferase |
Biological source | Staphylococcus aureus MRSA252 |
Total number of polymer chains | 6 |
Total formula weight | 179875.03 |
Authors | Kuenz, M.,Drebes, J.,Windshuegel, B.,Cang, H.,Wrenger, C.,Betzel, C. (deposition date: 2015-07-09, release date: 2016-03-23, Last modification date: 2024-05-08) |
Primary citation | Drebes, J.,Kunz, M.,Windshugel, B.,Kikhney, A.G.,Muller, I.B.,Eberle, R.J.,Oberthur, D.,Cang, H.,Svergun, D.I.,Perbandt, M.,Betzel, C.,Wrenger, C. Structure of ThiM from Vitamin B1 biosynthetic pathway of Staphylococcus aureus - Insights into a novel pro-drug approach addressing MRSA infections. Sci Rep, 6:22871-22871, 2016 Cited by PubMed: 26960569DOI: 10.1038/srep22871 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
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