5CGE

Structure of Hydroxyethylthiazole Kinase ThiM from Staphylococcus aureus in complex with substrate analog 2-(2-methyl-1H-imidazole-1-yl)ethanol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, E, D...)	Hydroxyethylthiazole kinase	polymer	277	29827.8	6	UniProt (Q6GEY3) Pfam (PF02110)	Staphylococcus aureus subsp. aureus MRSA252	4-methyl-5-beta-hydroxyethylthiazole kinase,Thz kinase
2	G, I, K, N, P... (A, B, C, E, D)	2-(2-methyl-1H-imidazol-1-yl)ethanol	non-polymer		126.2	6	Chemie (51F)
3	H, J, L, M, O (A, B, C, E)	MAGNESIUM ION	non-polymer		24.3	5	Chemie (MG)
4	R, S, T, U, V... (A, B, C, E, D...)	water	water		18.0	506	Chemie (HOH)

Sequence modifications

A, B, C, E, D, F: 1 - 263 (UniProt: Q6GEY3)

PDB	External Database	Details
Glu 264	-	expression tag
Asn 265	-	expression tag
Leu 266	-	expression tag
Tyr 267	-	expression tag
Phe 268	-	expression tag
Gln 269	-	expression tag
Ser 270	-	expression tag
Gly 271	-	expression tag
His 272	-	expression tag
His 273	-	expression tag
His 274	-	expression tag
His 275	-	expression tag
His 276	-	expression tag
His 277	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	178966.8
Non-Polymers*	Number of molecules	11
	Total formula weight	878.5
All*	Total formula weight	179845.3

*Water molecules are not included.