5CG2
Crystal structure of E. coli FabI bound to the thiocarbamoylated benzodiazaborine inhibitor 35b.
Summary for 5CG2
Entry DOI | 10.2210/pdb5cg2/pdb |
Related | 5CFZ 5CG1 |
Descriptor | Enoyl-[acyl-carrier-protein] reductase [NADH] FabI, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1-hydroxy-2,3,1-benzodiazaborinine-2(1H)-carbothioamide, ... (4 entities in total) |
Functional Keywords | antibiotics, nad, enoyl-acp reductase, oxidoreducatase-oxidoreducatase inhibitor complex, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Escherichia coli (strain K12) |
Total number of polymer chains | 2 |
Total formula weight | 67119.21 |
Authors | Jordan, C.A.,Vey, J.L. (deposition date: 2015-07-09, release date: 2015-12-09, Last modification date: 2023-09-27) |
Primary citation | Jordan, C.A.,Sandoval, B.A.,Serobyan, M.V.,Gilling, D.H.,Groziak, M.P.,Xu, H.H.,Vey, J.L. Crystallographic insights into the structure-activity relationships of diazaborine enoyl-ACP reductase inhibitors. Acta Crystallogr.,Sect.F, 71:1521-1530, 2015 Cited by PubMed: 26625295DOI: 10.1107/S2053230X15022098 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
Download full validation report