5CFT
Crystal Structure of ANT(2")-Ia in complex with AMPCPP and gentamicin C1
Summary for 5CFT
Entry DOI | 10.2210/pdb5cft/pdb |
Related | 4XJE 5CFS 5CFU |
Descriptor | Aminoglycoside Nucleotidyltransferase (2")-Ia, MANGANESE (II) ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... (6 entities in total) |
Functional Keywords | antibiotic resistance, nucleotidyltransferase, ampcpp, gentamicin, rossmann fold, transferase-antibiotic complex, transferase/antibiotic |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 1 |
Total formula weight | 22339.53 |
Authors | Rodionov, D.,Bassenden, A.V.,Berghuis, A.M. (deposition date: 2015-07-08, release date: 2016-03-16, Last modification date: 2024-03-06) |
Primary citation | Bassenden, A.V.,Rodionov, D.,Shi, K.,Berghuis, A.M. Structural Analysis of the Tobramycin and Gentamicin Clinical Resistome Reveals Limitations for Next-generation Aminoglycoside Design. Acs Chem.Biol., 11:1339-1346, 2016 Cited by PubMed: 26900880DOI: 10.1021/acschembio.5b01070 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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