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5CFT

Crystal Structure of ANT(2")-Ia in complex with AMPCPP and gentamicin C1

Summary for 5CFT
Entry DOI10.2210/pdb5cft/pdb
Related4XJE 5CFS 5CFU
DescriptorAminoglycoside Nucleotidyltransferase (2")-Ia, MANGANESE (II) ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... (6 entities in total)
Functional Keywordsantibiotic resistance, nucleotidyltransferase, ampcpp, gentamicin, rossmann fold, transferase-antibiotic complex, transferase/antibiotic
Biological sourcePseudomonas aeruginosa
Total number of polymer chains1
Total formula weight22339.53
Authors
Rodionov, D.,Bassenden, A.V.,Berghuis, A.M. (deposition date: 2015-07-08, release date: 2016-03-16, Last modification date: 2024-03-06)
Primary citationBassenden, A.V.,Rodionov, D.,Shi, K.,Berghuis, A.M.
Structural Analysis of the Tobramycin and Gentamicin Clinical Resistome Reveals Limitations for Next-generation Aminoglycoside Design.
Acs Chem.Biol., 11:1339-1346, 2016
Cited by
PubMed: 26900880
DOI: 10.1021/acschembio.5b01070
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

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