5CF0

Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ6

Summary for 5CF0

DescriptorHeat shock protein HSP 90-alpha, N-{3-[2,4-dihydroxy-5-(isoquinolin-4-yl)phenyl]-4-(4-methoxyphenyl)-1,2-oxazol-5-yl}cyclopropanecarboxamide (3 entities in total)
Functional Keywordsheat shock protein 90, n-terminal domain, inhibitor, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm P07900
Total number of polymer chains1
Total molecular weight26150.28
Authors
Li, J.,Shi, F.,Xiong, B.,He, J.H. (deposition date: 2015-07-08, release date: 2016-07-13, Last modification date: 2016-10-12)
Primary citation
Li, J.,Shi, F.,Chen, D.-Q.,Cao, H.-L.,Xiong, B.,Shen, J.-K.,He, J.-H.
FS23 binds to the N-terminal domain of human Hsp90: A novel small inhibitor for Hsp90
Nucl.Sci.Tech., 26:060502-060502, 2015
DOI: 10.13538/j.1001-8042/nst.26.060503
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.218102.8%3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-08-05