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5CEH

Structure of histone lysine demethylase KDM5A in complex with selective inhibitor

Summary for 5CEH
Entry DOI10.2210/pdb5ceh/pdb
DescriptorLysine-specific demethylase 5A, Unknown Peptide, NICKEL (II) ION, ... (6 entities in total)
Functional Keywordsepigenetics, demethylase, histone, kdm5a, kdm5, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological sourceHomo sapiens (Human)
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Cellular locationNucleus, nucleolus : P29375
Total number of polymer chains2
Total formula weight92040.82
Authors
Kiefer, J.R.,Vinogradova, M. (deposition date: 2015-07-06, release date: 2016-05-18, Last modification date: 2017-11-22)
Primary citationVinogradova, M.,Gehling, V.S.,Gustafson, A.,Arora, S.,Tindell, C.A.,Wilson, C.,Williamson, K.E.,Guler, G.D.,Gangurde, P.,Manieri, W.,Busby, J.,Flynn, E.M.,Lan, F.,Kim, H.J.,Odate, S.,Cochran, A.G.,Liu, Y.,Wongchenko, M.,Yang, Y.,Cheung, T.K.,Maile, T.M.,Lau, T.,Costa, M.,Hegde, G.V.,Jackson, E.,Pitti, R.,Arnott, D.,Bailey, C.,Bellon, S.,Cummings, R.T.,Albrecht, B.K.,Harmange, J.C.,Kiefer, J.R.,Trojer, P.,Classon, M.
An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells.
Nat.Chem.Biol., 12:531-538, 2016
Cited by
PubMed: 27214401
DOI: 10.1038/nchembio.2085
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.14 Å)
Structure validation

217705

건을2024-03-27부터공개중

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