5CEH
Structure of histone lysine demethylase KDM5A in complex with selective inhibitor
Summary for 5CEH
Entry DOI | 10.2210/pdb5ceh/pdb |
Descriptor | Lysine-specific demethylase 5A, Unknown Peptide, NICKEL (II) ION, ... (6 entities in total) |
Functional Keywords | epigenetics, demethylase, histone, kdm5a, kdm5, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus, nucleolus : P29375 |
Total number of polymer chains | 2 |
Total formula weight | 92040.82 |
Authors | Kiefer, J.R.,Vinogradova, M. (deposition date: 2015-07-06, release date: 2016-05-18, Last modification date: 2017-11-22) |
Primary citation | Vinogradova, M.,Gehling, V.S.,Gustafson, A.,Arora, S.,Tindell, C.A.,Wilson, C.,Williamson, K.E.,Guler, G.D.,Gangurde, P.,Manieri, W.,Busby, J.,Flynn, E.M.,Lan, F.,Kim, H.J.,Odate, S.,Cochran, A.G.,Liu, Y.,Wongchenko, M.,Yang, Y.,Cheung, T.K.,Maile, T.M.,Lau, T.,Costa, M.,Hegde, G.V.,Jackson, E.,Pitti, R.,Arnott, D.,Bailey, C.,Bellon, S.,Cummings, R.T.,Albrecht, B.K.,Harmange, J.C.,Kiefer, J.R.,Trojer, P.,Classon, M. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat.Chem.Biol., 12:531-538, 2016 Cited by PubMed: 27214401DOI: 10.1038/nchembio.2085 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.14 Å) |
Structure validation
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