5C9J

Human CD1c with ligands in A' and F' channel

Summary for 5C9J

DescriptorT-cell surface glycoprotein CD1c,T-cell surface glycoprotein CD1b, Beta-2-microglobulin, LAURIC ACID, ... (7 entities in total)
Functional Keywordsantigen presentation, cd1, human cd1, mhc-like, immunology, lipid antigen, immune system
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane ; Single- pass type I membrane protein  P29016
Secreted  P61769
Total number of polymer chains2
Total molecular weight44463.82
Authors
Tews, I.,Machelett, M.M.,Mansour, S.,Gadola, S.D. (deposition date: 2015-06-27, release date: 2016-03-02, Last modification date: 2016-03-09)
Primary citation
Mansour, S.,Tocheva, A.S.,Cave-Ayland, C.,Machelett, M.M.,Sander, B.,Lissin, N.M.,Molloy, P.E.,Baird, M.S.,Stubs, G.,Schroder, N.W.,Schumann, R.R.,Rademann, J.,Postle, A.D.,Jakobsen, B.K.,Marshall, B.G.,Gosain, R.,Elkington, P.T.,Elliott, T.,Skylaris, C.K.,Essex, J.W.,Tews, I.,Gadola, S.D.
Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells.
Proc.Natl.Acad.Sci.USA, 113:E1266-E1275, 2016
PubMed: 26884207 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1519246113
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.204402.4%0.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5c9j
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Molmil generated image of 5c9j
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