5C8I

Joint X-ray/neutron structure of Human Carbonic Anhydrase II in complex with Methazolamide

5C8I の概要

• エントリーDOI: 10.2210/pdb5c8i/pdb
• 関連するPDBエントリー: 4G0C
• 分子名称: Carbonic anhydrase 2, ZINC ION, N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide, ... (4 entities in total)
• 機能のキーワード: methazolamide, acetazolamide, water displacement, lyase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29590.74

構造登録者

Aggarwal, M.,Kovalevsky, A.Y.,Fisher, S.Z.,McKenna, R. (登録日: 2015-06-25, 公開日: 2016-07-20, 最終更新日: 2024-03-06)

• 主引用文献: Aggarwal, M.,Kovalevsky, A.Y.,Velazquez, H.,Fisher, S.Z.,Smith, J.C.,McKenna, R.; Neutron structure of human carbonic anhydrase II in complex with methazolamide: mapping the solvent and hydrogen-bonding patterns of an effective clinical drug.; IUCrJ, 3:319-325, 2016; PubMed: 28461893; DOI: 10.1107/S2052252516010514

実験手法

NEUTRON DIFFRACTION (2.2 Å)
X-RAY DIFFRACTION (1.56 Å)