5C3G

Crystal structure of Bcl-xl bound to BIM-MM

5C3G の概要

• エントリーDOI: 10.2210/pdb5c3g/pdb
• 分子名称: Bcl-2-like protein 1,Bcl-2-like protein 1, Bcl-2-like protein 11 (3 entities in total)
• 機能のキーワード: complex, bcl-2 family, bh3, stapled peptide, apoptosis
• 由来する生物種: Mus musculus (House Mouse); 詳細
• 細胞内の位置: Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817; Endomembrane system ; Peripheral membrane protein . Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion: O43521
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 20117.53

構造登録者

Miles, J.A.,Yeo, D.J.,Rowell, P.,Rodriguez-Marin, S.,Pask, C.M.,Warriner, S.L.,Edwards, T.A.,Wilson, A.J. (登録日: 2015-06-17, 公開日: 2016-04-20, 最終更新日: 2024-01-10)

• 主引用文献: Miles, J.A.,Yeo, D.J.,Rowell, P.,Rodriguez-Marin, S.,Pask, C.M.,Warriner, S.L.,Edwards, T.A.,Wilson, A.J.; Hydrocarbon constrained peptides - understanding preorganisation and binding affinity.; Chem Sci, 7:3694-3702, 2016; PubMed: 28970875; DOI: 10.1039/c5sc04048e

実験手法

X-RAY DIFFRACTION (2.45 Å)