5C1D

Human OGT in complex with UDP-5S-GlcNAc and substrate peptide (RB2L)

5C1D の概要

• エントリーDOI: 10.2210/pdb5c1d/pdb
• 分子名称: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Retinoblastoma-like protein 2, (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, ... (5 entities in total)
• 機能のキーワード: o-glcnac transferase inverting gt-b substrate complex, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Isoform 2: Mitochondrion. Isoform 3: Cytoplasm. Isoform 4: Cytoplasm: O15294; Nucleus: Q08999
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82532.70

構造登録者

Schimpl, M.,Rafie, K.,van Aalten, D.M.F. (登録日: 2015-06-13, 公開日: 2015-08-05, 最終更新日: 2024-01-10)

• 主引用文献: Pathak, S.,Alonso, J.,Schimpl, M.,Rafie, K.,Blair, D.E.,Borodkin, V.S.,Schuttelkopf, A.W.,Albarbarawi, O.,van Aalten, D.M.; The active site of O-GlcNAc transferase imposes constraints on substrate sequence.; Nat.Struct.Mol.Biol., 22:744-750, 2015; PubMed: 26237509; DOI: 10.1038/nsmb.3063

実験手法

X-RAY DIFFRACTION (2.05 Å)