5C0N
Development of a monoclonal antibody targeting secreted aP2 to treat diabetes and fatty liver disease
Summary for 5C0N
Entry DOI | 10.2210/pdb5c0n/pdb |
Descriptor | Fatty acid-binding protein, adipocyte, Fab CA33 Heavy chain, Fab CA33 light chain (3 entities in total) |
Functional Keywords | ap2, fabp4, fab, type ii diabetes, lipid transport |
Biological source | Mus musculus (House Mouse) More |
Cellular location | Cytoplasm: P04117 |
Total number of polymer chains | 6 |
Total formula weight | 124139.16 |
Authors | Doyle, C. (deposition date: 2015-06-12, release date: 2015-06-24, Last modification date: 2024-01-10) |
Primary citation | Burak, M.F.,Inouye, K.E.,White, A.,Lee, A.,Tuncman, G.,Calay, E.S.,Sekiya, M.,Tirosh, A.,Eguchi, K.,Birrane, G.,Lightwood, D.,Howells, L.,Odede, G.,Hailu, H.,West, S.,Garlish, R.,Neale, H.,Doyle, C.,Moore, A.,Hotamisligil, G.S. Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. Sci Transl Med, 7:319ra205-319ra205, 2015 Cited by PubMed: 26702093DOI: 10.1126/scitranslmed.aac6336 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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