5C0N

Development of a monoclonal antibody targeting secreted aP2 to treat diabetes and fatty liver disease

5C0N の概要

• エントリーDOI: 10.2210/pdb5c0n/pdb
• 分子名称: Fatty acid-binding protein, adipocyte, Fab CA33 Heavy chain, Fab CA33 light chain (3 entities in total)
• 機能のキーワード: ap2, fabp4, fab, type ii diabetes, lipid transport
• 由来する生物種: Mus musculus (House Mouse); 詳細
• 細胞内の位置: Cytoplasm: P04117
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 124139.16

構造登録者

Doyle, C. (登録日: 2015-06-12, 公開日: 2015-06-24, 最終更新日: 2024-01-10)

• 主引用文献: Burak, M.F.,Inouye, K.E.,White, A.,Lee, A.,Tuncman, G.,Calay, E.S.,Sekiya, M.,Tirosh, A.,Eguchi, K.,Birrane, G.,Lightwood, D.,Howells, L.,Odede, G.,Hailu, H.,West, S.,Garlish, R.,Neale, H.,Doyle, C.,Moore, A.,Hotamisligil, G.S.; Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.; Sci Transl Med, 7:319ra205-319ra205, 2015; PubMed: 26702093; DOI: 10.1126/scitranslmed.aac6336

実験手法

X-RAY DIFFRACTION (3 Å)