5BYZ

ERK5 in complex with small molecule

Summary for 5BYZ

Entry DOI	10.2210/pdb5byz/pdb
Descriptor	Mitogen-activated protein kinase 7, 4-({5-fluoro-4-[2-methyl-1-(propan-2-yl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)-N-[2-(piperidin-1-yl)ethyl]benzamide, GLYCEROL, ... (4 entities in total)
Functional Keywords	erk5, kinase inhibitor, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q13164
Total number of polymer chains	1
Total formula weight	40844.99
Authors	Chen, H.,Tucker, J.,Wang, X.,Gavine, P.R.,Philips, C.,Augustin, M.A.,Schreiner, P.,Steinbacher, S.,Preston, M.,Ogg, D. (deposition date: 2015-06-11, release date: 2016-05-04, Last modification date: 2016-05-11)
Primary citation	Chen, H.,Tucker, J.,Wang, X.,Gavine, P.R.,Phillips, C.,Augustin, M.A.,Schreiner, P.,Steinbacher, S.,Preston, M.,Ogg, D. Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site. Acta Crystallogr D Struct Biol, 72:682-693, 2016 Cited by PubMed: 27139631 DOI: 10.1107/S2059798316004502 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation