5BYZ
ERK5 in complex with small molecule
Summary for 5BYZ
Entry DOI | 10.2210/pdb5byz/pdb |
Descriptor | Mitogen-activated protein kinase 7, 4-({5-fluoro-4-[2-methyl-1-(propan-2-yl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)-N-[2-(piperidin-1-yl)ethyl]benzamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | erk5, kinase inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q13164 |
Total number of polymer chains | 1 |
Total formula weight | 40844.99 |
Authors | Chen, H.,Tucker, J.,Wang, X.,Gavine, P.R.,Philips, C.,Augustin, M.A.,Schreiner, P.,Steinbacher, S.,Preston, M.,Ogg, D. (deposition date: 2015-06-11, release date: 2016-05-04, Last modification date: 2016-05-11) |
Primary citation | Chen, H.,Tucker, J.,Wang, X.,Gavine, P.R.,Phillips, C.,Augustin, M.A.,Schreiner, P.,Steinbacher, S.,Preston, M.,Ogg, D. Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site. Acta Crystallogr D Struct Biol, 72:682-693, 2016 Cited by PubMed: 27139631DOI: 10.1107/S2059798316004502 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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