5BYY
ERK5 IN COMPLEX WITH SMALL MOLECULE
Summary for 5BYY
Entry DOI | 10.2210/pdb5byy/pdb |
Descriptor | Mitogen-activated protein kinase 7, 2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one (3 entities in total) |
Functional Keywords | erk5 kinase, kinase inhibitor, proteros biostructures gmbh, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q13164 |
Total number of polymer chains | 1 |
Total formula weight | 40087.15 |
Authors | Chen, H.,Tucker, J.,Wang, X.,Gavine, P.R.,Philips, C.,Augustin, M.A.,Schreiner, P.,Steinbacher, S.,Preston, M.,Ogg, D. (deposition date: 2015-06-11, release date: 2016-05-04, Last modification date: 2024-05-08) |
Primary citation | Chen, H.,Tucker, J.,Wang, X.,Gavine, P.R.,Phillips, C.,Augustin, M.A.,Schreiner, P.,Steinbacher, S.,Preston, M.,Ogg, D. Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site. Acta Crystallogr D Struct Biol, 72:682-693, 2016 Cited by PubMed: 27139631DOI: 10.1107/S2059798316004502 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.79 Å) |
Structure validation
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