5BYY

ERK5 IN COMPLEX WITH SMALL MOLECULE

Summary for 5BYY

• Entry DOI: 10.2210/pdb5byy/pdb
• Descriptor: Mitogen-activated protein kinase 7, 2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one (3 entities in total)
• Functional Keywords: erk5 kinase, kinase inhibitor, proteros biostructures gmbh, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q13164
• Total number of polymer chains: 1
• Total formula weight: 40087.15

Authors

Chen, H.,Tucker, J.,Wang, X.,Gavine, P.R.,Philips, C.,Augustin, M.A.,Schreiner, P.,Steinbacher, S.,Preston, M.,Ogg, D. (deposition date: 2015-06-11, release date: 2016-05-04, Last modification date: 2016-05-11)

• Primary citation: Chen, H.,Tucker, J.,Wang, X.,Gavine, P.R.,Phillips, C.,Augustin, M.A.,Schreiner, P.,Steinbacher, S.,Preston, M.,Ogg, D.; Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.; Acta Crystallogr D Struct Biol, 72:682-693, 2016; PubMed: 27139631; DOI: 10.1107/S2059798316004502

Experimental method

X-RAY DIFFRACTION (2.79 Å)