5BYY

ERK5 IN COMPLEX WITH SMALL MOLECULE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004707	molecular_function	MAP kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue 4WG A 401

Chain	Residue
A	ILE61
A	HOH507
A	ARG75
A	LEU76
A	LEU137
A	ASP138
A	MET140
A	GLU141
A	SER186
A	LEU189

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGNGAYGVVSsArrrltgqqv.........AIKK

Chain	Residue	Details
A	ILE61-LYS85

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDLKpsNLLV

Chain	Residue	Details
A	VAL178-VAL190

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site_id	PS01351
Number of Residues	105
Details	MAPK MAP kinase signature. FdvvtnakrtlRElkilkhfkhdniiaikdilrptvpygefksvyvvldlmesdlhqiihssqpltlehvryflyqllrglkymhsaqvih........RDlKpsnllvnenC

Chain	Residue	Details
A	PHE90-CYS194

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	61
Details	Region: {"description":"Required for binding to MAP2K5","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Motif: {"description":"TXY"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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