5BYB

Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 1,5-(PA)2-IP4

5BYB の概要

• エントリーDOI: 10.2210/pdb5byb/pdb
• 関連するPDBエントリー: 5BYA
• 分子名称: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, ADENOSINE-5'-DIPHOSPHATE, {[(1R,3S,4S,5R,6S)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl]bis[oxy(2-oxoethane-2,1-diyl)]}bis(phosphonic acid), ... (7 entities in total)
• 機能のキーワード: methylenebisphosphonate, phosphonoacetate, non-hydrolyzable, pyrophosphate mimics, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytosol : O43314
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39238.52

構造登録者

Wang, H.,Shears, S.B. (登録日: 2015-06-10, 公開日: 2015-07-22, 最終更新日: 2023-09-27)

• 主引用文献: Riley, A.M.,Wang, H.,Shears, S.B.,L Potter, B.V.; Synthetic tools for studying the chemical biology of InsP8.; Chem.Commun.(Camb.), 51:12605-12608, 2015; PubMed: 26153667; DOI: 10.1039/c5cc05017k

実験手法

X-RAY DIFFRACTION (2.3 Å)