5BXS

LNBase in complex with LNB-NHAcCAS

Summary for 5BXS

Entry DOI	10.2210/pdb5bxs/pdb
Related	5BXP 5BXR 5BXT
Descriptor	Lacto-N-biosidase, beta-D-galactopyranose, 6-ACETAMIDO-6-DEOXY-CASTANOSPERMINE, ... (5 entities in total)
Functional Keywords	tim barrel, hydrolase, distal gut, human milk oligosaccharides, inhibitor
Biological source	Bifidobacterium bifidum JCM 1254
Total number of polymer chains	2
Total formula weight	144797.41
Authors	Ito, T.,Arakawa, T.,Fushinobu, S. (deposition date: 2015-06-09, release date: 2015-09-09, Last modification date: 2024-10-30)
Primary citation	Hattie, M.,Ito, T.,Debowski, A.W.,Arakawa, T.,Katayama, T.,Yamamoto, K.,Fushinobu, S.,Stubbs, K.A. Gaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysis Chem.Commun.(Camb.), 51:15008-15011, 2015 Cited by PubMed Abstract: The synthesis of potent inhibitors for lacto-N-biosidases and X-ray structural characterization of these compounds in complex with BbLNBase is described. PubMed: 26312778 DOI: 10.1039/c5cc05494j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation