5BWZ

Crystal structure of S39E HDAC8 in complex with Droxinostat

5BWZ の概要

• エントリーDOI: 10.2210/pdb5bwz/pdb
• 分子名称: Histone deacetylase 8, ZINC ION, POTASSIUM ION, ... (6 entities in total)
• 機能のキーワード: arginase/deacetylase fold, hydrolase, histone deacetylase, enzyme inhibitor-complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 87414.73

構造登録者

Decroos, C.,Christianson, D.W. (登録日: 2015-06-08, 公開日: 2016-06-08, 最終更新日: 2023-09-27)

• 主引用文献: Welker Leng, K.R.,Castaneda, C.A.,Decroos, C.,Islam, B.,Haider, S.M.,Christianson, D.W.,Fierke, C.A.; Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of the Phosphomimetic S39E Mutant.; Biochemistry, 58:4480-4493, 2019; PubMed: 31633931; DOI: 10.1021/acs.biochem.9b00653

実験手法

X-RAY DIFFRACTION (1.59 Å)