5BW6

Tryptophan Synthase from Salmonella typhimurium in complex with a single molecule of 2-({[4-(trifluoromethoxy)phenyl]carbonyl}amino)ethyl dihydrogen phosphate (F6) in the alpha-site.

5BW6 の概要

• エントリーDOI: 10.2210/pdb5bw6/pdb
• 関連するPDBエントリー: 2CLE 2CLF 2CLM 4WX2 4Y6G 4ZQC
• 分子名称: Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL DIHYDROGEN PHOSPHATE, ... (6 entities in total)
• 機能のキーワード: carbon-oxygen lyase, tryptophan biosynthesis, salmonella typhimurium, f6f, inhibitor, allosteric enzyme, aromatic amino acid biosynthesis, pyridoxal phosphate, transferase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Salmonella enterica subsp. enterica serovar Typhimurium; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72216.97

構造登録者

Hilario, E.,Caulkins, B.G.,Young, R.P.,Niks, D.,Dunn, M.F.,Mueller, L.J.,Fan, L. (登録日: 2015-06-06, 公開日: 2016-02-10, 最終更新日: 2023-09-27)

• 主引用文献: Hilario, E.,Caulkins, B.G.,Huang, Y.M.,You, W.,Chang, C.E.,Mueller, L.J.,Dunn, M.F.,Fan, L.; Visualizing the tunnel in tryptophan synthase with crystallography: Insights into a selective filter for accommodating indole and rejecting water.; Biochim.Biophys.Acta, 1864:268-279, 2016; PubMed: 26708480; DOI: 10.1016/j.bbapap.2015.12.006

実験手法

X-RAY DIFFRACTION (1.82 Å)