5BVK

Fragment-based discovery of potent and selective DDR1/2 inhibitors

Summary for 5BVK

Entry DOI	10.2210/pdb5bvk/pdb
Descriptor	Epithelial discoidin domain-containing receptor 1, IODIDE ION, 1-(2-chlorophenyl)-3-(pyridin-3-ylmethyl)urea, ... (4 entities in total)
Functional Keywords	ddr1, transferase
Biological source	Homo sapiens (Human)
Cellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Secreted . Isoform 4: Cell membrane; Single-pass type I membrane protein: Q08345
Total number of polymer chains	1
Total formula weight	37458.92
Authors	Murray, C.,Berdini, V.,Buck, I.,Carr, M.,Cleasby, A.,Coyle, J.,Curry, J.,Day, J.,Hearn, K.,Iqbal, A.,Lee, L.,Martins, V.,Mortenson, P.,Munck, J.,Page, L.,Patel, S.,Roomans, S.,Kirsten, T.,Saxty, G. (deposition date: 2015-06-05, release date: 2015-08-05)
Primary citation	Murray, C.W.,Berdini, V.,Buck, I.M.,Carr, M.E.,Cleasby, A.,Coyle, J.E.,Curry, J.E.,Day, J.E.,Day, P.J.,Hearn, K.,Iqbal, A.,Lee, L.Y.,Martins, V.,Mortenson, P.N.,Munck, J.M.,Page, L.W.,Patel, S.,Roomans, S.,Smith, K.,Tamanini, E.,Saxty, G. Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors. Acs Med.Chem.Lett., 6:798-803, 2015 Cited by PubMed: 26191369 DOI: 10.1021/acsmedchemlett.5b00143 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.29 Å)

Structure validation