5BTR
Crystal structure of SIRT1 in complex with resveratrol and an AMC-containing peptide
Summary for 5BTR
Entry DOI | 10.2210/pdb5btr/pdb |
Descriptor | NAD-dependent protein deacetylase sirtuin-1, AMC-containing peptide, ZINC ION, ... (5 entities in total) |
Functional Keywords | deacetylase, human sirtuin 1, n-terminal domain, catalytic domain, c-terminal domain, resveratrol, substrate, hydrolase-substrate complex, hydrolase/substrate |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus, PML body . SirtT1 75 kDa fragment: Cytoplasm : Q96EB6 |
Total number of polymer chains | 6 |
Total formula weight | 139759.39 |
Authors | |
Primary citation | Cao, D.,Wang, M.,Qiu, X.,Liu, D.,Jiang, H.,Yang, N.,Xu, R.M. Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol Genes Dev., 29:1316-1325, 2015 Cited by PubMed: 26109052DOI: 10.1101/gad.265462.115 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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