5BTR

Crystal structure of SIRT1 in complex with resveratrol and an AMC-containing peptide

5BTR の概要

• エントリーDOI: 10.2210/pdb5btr/pdb
• 分子名称: NAD-dependent protein deacetylase sirtuin-1, AMC-containing peptide, ZINC ION, ... (5 entities in total)
• 機能のキーワード: deacetylase, human sirtuin 1, n-terminal domain, catalytic domain, c-terminal domain, resveratrol, substrate, hydrolase-substrate complex, hydrolase/substrate
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus, PML body . SirtT1 75 kDa fragment: Cytoplasm : Q96EB6
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 139759.39

構造登録者

Cao, D.,Wang, M.,Qiu, X.,Liu, D.,Jiang, H.,Yang, N.,Xu, R.M. (登録日: 2015-06-03, 公開日: 2015-07-08, 最終更新日: 2023-11-08)

• 主引用文献: Cao, D.,Wang, M.,Qiu, X.,Liu, D.,Jiang, H.,Yang, N.,Xu, R.M.; Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol; Genes Dev., 29:1316-1325, 2015; PubMed: 26109052; DOI: 10.1101/gad.265462.115

実験手法

X-RAY DIFFRACTION (3.2 Å)