5BT4

Crystal structure of BRD4 first bromodomain in complex with SGC-CBP30 chemical probe

5BT4 の概要

• エントリーDOI: 10.2210/pdb5bt4/pdb
• 分子名称: Bromodomain-containing protein 4, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: chromatin and transcription regulator, acetylation, structural genomics, structural genomics consortium, sgc, transcription
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 46949.40

構造登録者

Tallant, C.,Hay, D.,Krojer, T.,Nunez-Alonso, G.,Picaud, S.,Newman, J.A.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Brennan, P.E.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2015-06-02, 公開日: 2015-07-01, 最終更新日: 2024-05-08)

• 主引用文献: Tallant, C.,Hay, D.,Krojer, T.,Nunez-Alonso, G.,Picaud, S.,Newman, J.A.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Brennan, P.E.,Knapp, S.; Crystal structure of BRD4 first bromodomain in complex with a 3,5-dimethylisoxazol ligand; To Be Published,

実験手法

X-RAY DIFFRACTION (1.5 Å)