5BSK
Human HGPRT in complex with (S)-HPEPG, an acyclic nucleoside phosphonate
Summary for 5BSK
Entry DOI | 10.2210/pdb5bsk/pdb |
Related | 5BRN |
Descriptor | Hypoxanthine-guanine phosphoribosyltransferase, (2-{[(2S)-1-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-hydroxypropan-2-yl]oxy}ethyl)phosphonic acid, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | hypoxanthine-guanine-phosphoribosyltransferase, malaria, acyclic nucleoside phosphonates, inhibitors, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P00492 |
Total number of polymer chains | 4 |
Total formula weight | 99495.04 |
Authors | Keough, D.T.,Guddat, L.W.,Kaiser, M.M.,Hockova, D.,Wang, T.-H.,Janeba, Z. (deposition date: 2015-06-02, release date: 2015-09-23, Last modification date: 2023-09-27) |
Primary citation | Kaiser, M.M.,Hockova, D.,Wang, T.H.,Dracinsky, M.,Postova-Slavetinska, L.,Prochazkova, E.,Edstein, M.D.,Chavchich, M.,Keough, D.T.,Guddat, L.W.,Janeba, Z. Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases. Chemmedchem, 10:1707-1723, 2015 Cited by PubMed: 26368337DOI: 10.1002/cmdc.201500322 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
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