5BSK

Human HGPRT in complex with (S)-HPEPG, an acyclic nucleoside phosphonate

5BSK の概要

• エントリーDOI: 10.2210/pdb5bsk/pdb
• 関連するPDBエントリー: 5BRN
• 分子名称: Hypoxanthine-guanine phosphoribosyltransferase, (2-{[(2S)-1-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-hydroxypropan-2-yl]oxy}ethyl)phosphonic acid, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: hypoxanthine-guanine-phosphoribosyltransferase, malaria, acyclic nucleoside phosphonates, inhibitors, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P00492
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 99495.04

構造登録者

Keough, D.T.,Guddat, L.W.,Kaiser, M.M.,Hockova, D.,Wang, T.-H.,Janeba, Z. (登録日: 2015-06-02, 公開日: 2015-09-23, 最終更新日: 2023-09-27)

• 主引用文献: Kaiser, M.M.,Hockova, D.,Wang, T.H.,Dracinsky, M.,Postova-Slavetinska, L.,Prochazkova, E.,Edstein, M.D.,Chavchich, M.,Keough, D.T.,Guddat, L.W.,Janeba, Z.; Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases.; Chemmedchem, 10:1707-1723, 2015; PubMed: 26368337; DOI: 10.1002/cmdc.201500322

実験手法

X-RAY DIFFRACTION (2.61 Å)