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5BS3

Crystal Structure of S.A. gyrase in complex with Compound 7

Summary for 5BS3
Entry DOI10.2210/pdb5bs3/pdb
DescriptorDNA gyrase subunit A and B, DNA/RNA (5'-R(P*AP*GP*CP*CP*G)-D(P*T)-R(P*AP*GP*GP*GP*CP*CP*C)-D(P*T)-R(P*AP*CP*GP*GP*C)-D(P*T)-3'), MANGANESE (II) ION, ... (6 entities in total)
Functional Keywordsgyrase, antibacterial, sar, complex, isomerase-dna-rna complex, isomerase/dna/rna
Biological sourceStaphylococcus aureus
More
Cellular locationCytoplasm : P20831
Total number of polymer chains4
Total formula weight169871.33
Authors
Lu, J.,Patel, S.,Soisson, S. (deposition date: 2015-06-01, release date: 2015-06-17, Last modification date: 2024-03-06)
Primary citationSingh, S.B.,Kaelin, D.E.,Wu, J.,Miesel, L.,Tan, C.M.,Black, T.,Nargund, R.,Meinke, P.T.,Olsen, D.B.,Lagrutta, A.,Lu, J.,Patel, S.,Rickert, K.W.,Smith, R.F.,Soisson, S.,Sherer, E.,Joyce, L.A.,Wei, C.,Peng, X.,Wang, X.,Fukuda, H.,Kishii, R.,Takei, M.,Takano, H.,Shibasaki, M.,Yajima, M.,Nishimura, A.,Shibata, T.,Fukuda, Y.
Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2).
Bioorg.Med.Chem.Lett., 25:1831-1835, 2015
Cited by
PubMed: 25851938
DOI: 10.1016/j.bmcl.2015.03.044
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.65 Å)
Structure validation

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건을2024-09-18부터공개중

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