5BS3

Crystal Structure of S.A. gyrase in complex with Compound 7

Summary for 5BS3

• Entry DOI: 10.2210/pdb5bs3/pdb
• Descriptor: DNA gyrase subunit A and B, DNA/RNA (5'-R(P*AP*GP*CP*CP*G)-D(P*T)-R(P*AP*GP*GP*GP*CP*CP*C)-D(P*T)-R(P*AP*CP*GP*GP*C)-D(P*T)-3'), MANGANESE (II) ION, ... (6 entities in total)
• Functional Keywords: gyrase, antibacterial, sar, complex, isomerase-dna-rna complex, isomerase/dna/rna
• Biological source: Staphylococcus aureus; More
• Cellular location: Cytoplasm : P20831
• Total number of polymer chains: 4
• Total formula weight: 169871.33

Authors

Lu, J.,Patel, S.,Soisson, S. (deposition date: 2015-06-01, release date: 2015-06-17, Last modification date: 2024-03-06)

• Primary citation: Singh, S.B.,Kaelin, D.E.,Wu, J.,Miesel, L.,Tan, C.M.,Black, T.,Nargund, R.,Meinke, P.T.,Olsen, D.B.,Lagrutta, A.,Lu, J.,Patel, S.,Rickert, K.W.,Smith, R.F.,Soisson, S.,Sherer, E.,Joyce, L.A.,Wei, C.,Peng, X.,Wang, X.,Fukuda, H.,Kishii, R.,Takei, M.,Takano, H.,Shibasaki, M.,Yajima, M.,Nishimura, A.,Shibata, T.,Fukuda, Y.; Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2).; Bioorg.Med.Chem.Lett., 25:1831-1835, 2015; PubMed: 25851938; DOI: 10.1016/j.bmcl.2015.03.044

Experimental method

X-RAY DIFFRACTION (2.65 Å)