5BQN

Crystal structure of the LHn fragment of botulinum neurotoxin type D, mutant H233Y E230Q

Summary for 5BQN

Entry DOI	10.2210/pdb5bqn/pdb
Descriptor	Botulinum neurotoxin type D,Botulinum neurotoxin type D, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID (3 entities in total)
Functional Keywords	botulinum neurotoxin, targeted secretion inhibitors, endopeptidase, type d, protein engineering, hydrolase
Biological source	Clostridium botulinum More
Cellular location	Botulinum neurotoxin D light chain: Secreted. Botulinum neurotoxin D heavy chain: Secreted: P19321
Total number of polymer chains	1
Total formula weight	102093.90
Authors	Masuyer, G.,Davies, J.R.,Moore, K.,Chaddock, J.A.,Acharya, K.R. (deposition date: 2015-05-29, release date: 2015-08-19, Last modification date: 2024-01-10)
Primary citation	Masuyer, G.,Davies, J.R.,Moore, K.,Chaddock, J.A.,Ravi Acharya, K. Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors. Sci Rep, 5:13397-13397, 2015 Cited by PubMed: 26324071 DOI: 10.1038/srep13397 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation