5BQH

Discovery of a Potent and Selective mPGES-1 Inhibitor for the Treatment of Pain

Summary for 5BQH

Entry DOI	10.2210/pdb5bqh/pdb
Descriptor	Prostaglandin E synthase, N-[4-(4-chlorophenyl)-1H-imidazol-2-yl]-2-(difluoromethyl)-5-{[(2-methylpropanoyl)amino]methyl}benzamide, GLUTATHIONE, ... (7 entities in total)
Functional Keywords	mpges-1, enzyme, integral membrane protein, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	18944.83
Authors	Fisher, M.J.,Schiffler, M.A.,Kuklish, S.L.,Antonysamy, S.,Luz, J.G. (deposition date: 2015-05-29, release date: 2016-04-13, Last modification date: 2024-03-06)
Primary citation	Schiffler, M.A.,Antonysamy, S.,Bhattachar, S.N.,Campanale, K.M.,Chandrasekhar, S.,Condon, B.,Desai, P.V.,Fisher, M.J.,Groshong, C.,Harvey, A.,Hickey, M.J.,Hughes, N.E.,Jones, S.A.,Kim, E.J.,Kuklish, S.L.,Luz, J.G.,Norman, B.H.,Rathmell, R.E.,Rizzo, J.R.,Seng, T.W.,Thibodeaux, S.J.,Woods, T.A.,York, J.S.,Yu, X.P. Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors. J.Med.Chem., 59:194-205, 2016 Cited by PubMed: 26653180 DOI: 10.1021/acs.jmedchem.5b01249 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.601 Å)

Structure validation