5BOY
X-RAY Co-structure of MMP-13 with ethyl 5-(1-methyl-1H-imidazol-5-yl)-1H-indole-2-Carboxylate
Summary for 5BOY
Entry DOI | 10.2210/pdb5boy/pdb |
Related | 5BPA |
Descriptor | Collagenase 3, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | ridgefield, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted, extracellular space, extracellular matrix : P45452 |
Total number of polymer chains | 2 |
Total formula weight | 39511.47 |
Authors | Farrow, N.A. (deposition date: 2015-05-27, release date: 2015-06-17, Last modification date: 2024-03-06) |
Primary citation | Taylor, S.J.,Abeywardane, A.,Liang, S.,Muegge, I.,Padyana, A.K.,Xiong, Z.,Hill-Drzewi, M.,Farmer, B.,Li, X.,Collins, B.,Li, J.X.,Heim-Riether, A.,Proudfoot, J.,Zhang, Q.,Goldberg, D.,Zuvela-Jelaska, L.,Zaher, H.,Li, J.,Farrow, N.A. Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J. Med. Chem., 54:8174-8187, 2011 Cited by PubMed: 22017539DOI: 10.1021/jm201129m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
Download full validation report