5BOT
X-RAY Co-structure of MMP-13 with ethyl 5-carbamoyl-1H-indole-2-carboxylate
Summary for 5BOT
| Entry DOI | 10.2210/pdb5bot/pdb |
| Related | 5BOY 5BPA |
| Descriptor | Collagenase 3, ethyl 5-carbamoyl-1H-indole-2-carboxylate, ZINC ION, ... (5 entities in total) |
| Functional Keywords | ridgefield, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 39437.34 |
| Authors | Farrow, N.A.,Padyana, A.K. (deposition date: 2015-05-27, release date: 2015-06-17, Last modification date: 2024-03-06) |
| Primary citation | Taylor, S.J.,Abeywardane, A.,Liang, S.,Muegge, I.,Padyana, A.K.,Xiong, Z.,Hill-Drzewi, M.,Farmer, B.,Li, X.,Collins, B.,Li, J.X.,Heim-Riether, A.,Proudfoot, J.,Zhang, Q.,Goldberg, D.,Zuvela-Jelaska, L.,Zaher, H.,Li, J.,Farrow, N.A. Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J. Med. Chem., 54:8174-8187, 2011 Cited by PubMed: 22017539DOI: 10.1021/jm201129m PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
Download full validation report
