5BOQ

Human insulin with intra-chain chemical crosslink between modified B24 and B29

Summary for 5BOQ

• Entry DOI: 10.2210/pdb5boq/pdb
• Related: 5BPO 5BQQ
• Descriptor: Insulin, SULFATE ION, ... (4 entities in total)
• Functional Keywords: hormone, chemical crosslink, b24-b29, specificity
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P01308 P01308
• Total number of polymer chains: 8
• Total formula weight: 23458.52

Authors

Brzozowski, A.M.,Turkenburg, J.P.,Jiracek, J.,Zakova, L. (deposition date: 2015-05-27, release date: 2016-02-03, Last modification date: 2024-01-10)

• Primary citation: Vikova, J.,Collinsova, M.,Kletvikova, E.,Budesinsky, M.,Kaplan, V.,Zakova, L.,Veverka, V.,Hexnerova, R.,Avino, R.J.,Strakova, J.,Selicharova, I.,Vanek, V.,Wright, D.W.,Watson, C.J.,Turkenburg, J.P.,Brzozowski, A.M.,Jiracek, J.; Rational steering of insulin binding specificity by intra-chain chemical crosslinking.; Sci Rep, 6:19431-19431, 2016; PubMed: 26792393; DOI: 10.1038/srep19431

Experimental method

X-RAY DIFFRACTION (1.7 Å)