5BO3

Bianthranilate-like inhibitor with 5 atom "line" and phosphonate "hook" fishing for hydrogen bond donors in Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)

5BO3 の概要

• エントリーDOI: 10.2210/pdb5bo3/pdb
• 関連するPDBエントリー: 3QR9 4IJ1 5BO2
• 分子名称: Anthranilate phosphoribosyltransferase, 2-[(2-carboxyphenyl)amino]-5-(4-phosphonobutoxy)benzoic acid, IMIDAZOLE, ... (4 entities in total)
• 機能のキーワード: inhibitor, complex, lobenzarit-like analogue, tb structural genomics consortium, tbsgc, magnesium binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78852.85

構造登録者

Evans, G.L.,Baker, E.N.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (登録日: 2015-05-27, 公開日: 2016-06-01, 最終更新日: 2023-09-27)

• 主引用文献: Evans, G.L.,Baker, E.N.,Lott, J.S.; Binding and mimicking of the phosphate-rich substrate, PRPP.; To be Published,

実験手法

X-RAY DIFFRACTION (1.75 Å)