5BNJ
CDK8/CYCC IN COMPLEX WITH 8-{3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)-phenyl]-pyridin- 4-yl}-2,8-diaza-spiro[4.5]decan-1-one
Summary for 5BNJ
Entry DOI | 10.2210/pdb5bnj/pdb |
Related | 4f7n |
Descriptor | Cyclin-dependent kinase 8, Cyclin-C, 8-{3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]pyridin-4-yl}-2,8-diazaspiro[4.5]decan-1-one, ... (5 entities in total) |
Functional Keywords | cdk8 kinase / cyclin c, transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : P49336 P24863 |
Total number of polymer chains | 2 |
Total formula weight | 80984.73 |
Authors | Musil, D.,Blagg, J.,Wienke, D. (deposition date: 2015-05-26, release date: 2015-10-14, Last modification date: 2024-05-08) |
Primary citation | Dale, T.,Clarke, P.A.,Esdar, C.,Waalboer, D.,Adeniji-Popoola, O.,Ortiz-Ruiz, M.J.,Mallinger, A.,Samant, R.S.,Czodrowski, P.,Musil, D.,Schwarz, D.,Schneider, K.,Stubbs, M.,Ewan, K.,Fraser, E.,TePoele, R.,Court, W.,Box, G.,Valenti, M.,de Haven Brandon, A.,Gowan, S.,Rohdich, F.,Raynaud, F.,Schneider, R.,Poeschke, O.,Blaukat, A.,Workman, P.,Schiemann, K.,Eccles, S.A.,Wienke, D.,Blagg, J. A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. Nat.Chem.Biol., 11:973-980, 2015 Cited by PubMed: 26502155DOI: 10.1038/nchembio.1952 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.64 Å) |
Structure validation
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